Which of the following should be used to help protect immunocompromised animals?

• A. Positive Pressure Rooms
• B. Personal Protective Equipment (PPE)
• C. Cage Change Cabinets
• D. All of the Above

Answer: (D)

Protecting immunocompromised animals relies on layered protections that combine environmental, engineering, and personal measures. A room with positive pressure helps keep outside contaminants from entering the animal area by pushing air out when doors are opened, reducing the chance of pathogens reaching the animals. Personal protective equipment acts as a barrier between staff and animals, lowering the risk of transfer of infectious agents. Cage change cabinets provide a controlled, clean-air environment during routine cage changes, minimizing aerosol spread and protecting both the animals and staff. When these controls are used together, they offer multiple, overlapping defenses against infection, which is essential for vulnerable animals. That’s why all of these measures are used to protect immunocompromised animals.