Removal of which gland leads to a deficiency in T cells?

Study for the AALAS Laboratory Animal Technician Test. Enhance your knowledge with comprehensive questions and detailed explanations. Prepare effectively for your LAT certification exam!

Multiple Choice

Removal of which gland leads to a deficiency in T cells?

Explanation:
T cells mature in the thymus, so removing that gland eliminates the main site where thymocytes develop into functional T lymphocytes. In the thymus, precursor cells from the bone marrow undergo education and selection to become mature T cells capable of recognizing antigens in the context of self-MHC. Without this maturation environment, the body cannot produce new naive T cells, leading to a deficiency in T cell–mediated immunity. The other glands listed regulate hormones and metabolism but are not involved in T cell maturation, so their removal does not specifically cause a T cell deficiency. Clinically, thymus absence or removal results in impaired cellular immunity due to reduced T cell numbers.

T cells mature in the thymus, so removing that gland eliminates the main site where thymocytes develop into functional T lymphocytes. In the thymus, precursor cells from the bone marrow undergo education and selection to become mature T cells capable of recognizing antigens in the context of self-MHC. Without this maturation environment, the body cannot produce new naive T cells, leading to a deficiency in T cell–mediated immunity. The other glands listed regulate hormones and metabolism but are not involved in T cell maturation, so their removal does not specifically cause a T cell deficiency. Clinically, thymus absence or removal results in impaired cellular immunity due to reduced T cell numbers.

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